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Article Summary: Bextra has been linked to Stevens Johnson Syndrome (Erythema Multiforme) which is a skin disorder resulting from an allergic reaction.
Stevens-Johnson Syndrome (Erythema multiforme) A Side Effect of Bextra Erythema multiforme
Alternative names
Lyell's syndrome; Stevens-Johnson syndrome; Toxic epidermal necrolysis
Definition
Erythema multiforme is a skin disorder resulting from an allergic reaction.
Causes, incidence, and risk factors
Erythema multiforme is a type of hypersensitivity (allergic) reaction that occurs in response to medications, infections, or illness. Medications associated with erythema multiforme include sulfonamides, penicillins, barbiturates, and phenytoin. Associated infections include herpes simplex and mycoplasma infections.
The exact cause is unknown. The disorder is believed to involve damage to the blood vessels of the skin with subsequent damage to skin tissues. Approximately 90% of erythema multiforme cases are associated with herpes simplex or Mycoplasma infections. The disorder occurs primarily in children and young adults.
Erythema multiforme may present with a classic skin lesion with or without systemic (whole body) symptoms. In Stevens-Johnson syndrome, the systemic symptoms are severe and the lesions are extensive, involving multiple body areas (especially the mucous membranes). Toxic epidermal necrolysis (TEN syndrome, or Lyell's syndrome) involves multiple large blisters (bullae) that coalesce, followed by sloughing of all or most of the skin and mucous membranes.
Symptoms
Skin lesion
Multiple
With sudden onset, may recur
May spread
May appear as nodule, papule, or macule
Central lesion surrounded by concentric rings of pallor and redness ("target", "iris", "bull's eye" shape)
May have vesicles and bullae (blisters of various sizes)
Located on the legs, arms, palms, hands, or feet
May involve the face or lips
Trunk is usually not involved
Usually symmetrical
Itching of the skin may be present
Fever
General ill feeling
Joint aches
Additional symptoms that may be associated with this disease:
Vision abnormalities
Dry eyes
Bloodshot eyes
Eye pain
Eye burning, itching and discharge
Mouth sores
Signs and tests
The diagnosis is primarily based on the appearance of the skin lesion and its typical symmetrical distribution, especially if there is a history of risk factors or associated diseases.
There may be a positive Nikolsky's sign.
A skin lesion biopsy and microscopic examination may be helpful to differentiate erythema multiforme from other disorders. Erythema multiforme may show tissue death and other changes. Microscopic examination of the tissue may also show antibody deposits.
Treatment
Treatment goals include control of the underlying causes or illnesses, treatment of the symptoms, and prevention of infection. Suspected medications should be discontinued.
Treatment of mild symptoms may include:
Moist compresses applied to skin lesions.
Medications such as antihistamines to control itching.
Over-the-counter medications (such as acetaminophen) to reduce fever and discomfort.
Topical anesthetics (especially for mouth lesions) to ease discomfort that interferes with eating and drinking.
Treatment of severe symptoms may include:
Hospitalization and treatment in an intensive care or burn care unit for severe cases, Stevens-Johnson syndrome, and toxic epidermal necrolysis
Systemic corticosteroids to control inflammation
Intravenous immunoglobulins (IVIG) to stop the process
Antibiotics to control secondary skin infections
Good hygiene and isolation from others may be required to prevent secondary infections.
Extensive skin involvement may cause the loss of large quantities of body fluids, causing shock in addition to the risk of infection. Intensive care with support of body systems may be required.
Skin grafting may be helpful in cases in which large areas of the body are affected.
In cases that are caused by the herpes virus, daily antiviral medications may be prescribed to prevent recurrences of erythema multiforme.
Expectations (prognosis)
Mild forms of erythema multiforme usually resolve without difficulty in 2 to 6 weeks, but they may recur. More severe forms may be difficult to treat. Stevens-Johnson syndrome and toxic epidermal necrolysis are associated with high death rates.
Complications Return to top
Permanent skin damage and scarring
Occasionally, lesions on internal organs causing:
Pneumonitis (lung inflammation)
Myocarditis (heart inflammation)
Nephritis (kidney inflammation)
Hepatitis (liver inflammation)
Secondary skin infection (cellulitis)
Systemic infection, sepsis
Loss of body fluids, shock
Calling your health care provider
Go to the emergency room or call the local emergency number (such as 911) if symptoms indicate erythema multiforme. Involvement of a large area of the body is an emergency situation.
Update Date: 4/15/2003 If you or anyone you know has taken BEXTRA and has experienced the above symptoms or side effects, contact our BEXTRA lawyer and receive a free case evaluation.
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